Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75

@inproceedings{Krumbholz2015VeryLN,
  title={Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75},
  author={Markus Krumbholz and Ulrich Hofstadt-van Oy and Klemens Angstwurm and Ingo Kleiter and Sven Jarius and Friedemann Paul and Orhan Aktas and Grete Buchholz and Peter Christoph Kern and Andreas M. Straube and Tania Kuempfel},
  booktitle={Journal of Neurology},
  year={2015}
}
Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially seemed unlikely because of their age and age-associated concomitant diseases, and briefly review the literature. All three patients, aged 79, 82 and 88 years, presented with a spinal… CONTINUE READING

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