Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.

@article{Shin2013VeryLG,
  title={Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.},
  author={Daesung Shin and Shu-Ting Lin and Ying-Hui Fu and Louis J. Pt{\'a}cek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 47},
  pages={19101-6}
}
VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains. A truncating mutation in the Mass1 gene causes autosomal recessive, sound-induced seizures in the Frings mouse. However, the function of MASS1 and the mechanism underlying Frings mouse epilepsy are not known. Here, we found that MASS1 protein is enriched in the… CONTINUE READING