Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies

@article{Green2006VeryHI,
  title={Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies},
  author={Roger C. Green and Jane S. Green and Salome K B{\"u}hler and John Desmond Robb and Darshana Daftary and Steven Gallinger and John R McLaughlin and Patrick S. Parfrey and H. B. Younghusband},
  journal={Familial Cancer},
  year={2006},
  volume={6},
  pages={53-62}
}
Newfoundland has the highest rate of colorectal cancer (CRC) of any Canadian province. In order to investigate the factors, especially genetic components, responsible for CRC we established the Newfoundland Colorectal Cancer Registry. In a 5-year period we examined every case of CRC diagnosed under the age of 75 years and obtained consent from 730 cases. Careful analysis of family history was used to assign a familial cancer risk, based on established criteria. We observed that 3.7% of CRC… CONTINUE READING