Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice

@article{Breuer1989VeryHF,
  title={Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice},
  author={Marco Breuer and Robert J. C. Slebos and Sjef S Verbeek and Maarten van Lohuizen and Ellen Wientjens and Anton Berns},
  journal={Nature},
  year={1989},
  volume={340},
  pages={61-63}
}
INFECTION of mice with Moloney murine leukaemia virus (MuLV) induces T-cell lymphomas after an average latency period of 150 days. In these lymphomas the MuLV DNA is frequently integrated into the mouse chromosomal DNA in the vicinity of the pim-1 oncogene1. Transgenic mice overexpressing the pim-1 oncogene are predisposed to develop T-cell lymphomas, but only to the extent that ∼10% of the mice develop a lymphoma within 240 days. When these mice are infected with MuLV, lymphomas develop in all… CONTINUE READING
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