Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.

@article{Clifton2011VeryEH,
  title={Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.},
  author={Guy L. Clifton and Alex B. Valadka and David A. Zygun and Christopher S. Coffey and Pamala Drever and Sierra Fourwinds and L. Scott Janis and Elizabeth Wilde and Pauline Taylor and Kathy J Harshman and Adam Conley and Ava M. Puccio and Harvey S. Levin and Stephen R. McCauley and Richard D. Bucholz and Kenneth R. Smith and John E. Schmidt and J Nicholson Scott and Howard Yonas and David O. Okonkwo},
  journal={The Lancet. Neurology},
  year={2011},
  volume={10 2},
  pages={131-9}
}
BACKGROUND The inconsistent effect of hypothermia treatment on severe brain injury in previous trials might be because hypothermia was induced too late after injury. We aimed to assess whether very early induction of hypothermia improves outcome in patients with severe brain injury. METHODS The National Acute Brain Injury Study: Hypothermia II (NABIS: H II) was a randomised, multicentre clinical trial of patients with severe brain injury who were enrolled within 2·5 h of injury at six sites… CONTINUE READING
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