Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.

@article{Sanso2002VeryED,
  title={Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.},
  author={Gabriela E Sanso and Horacio M Domen{\'e} and R O Garcia and Eduardo Pusiol and M De and Maria del Pilar Roque and Alejandro Ring and H{\'e}ctor Perinetti and Boris Elsner and Sonia Iorcansky and Marta B. Barontini},
  journal={Cancer},
  year={2002},
  volume={94 2},
  pages={323-30}
}
BACKGROUND Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disease caused by germline mutations in the RET proto-oncogene, and is responsible for the development of endocrine neoplasia. Its prognosis is dependent on the appearance and spread of medullary thyroid carcinoma (MTC). Relatives at risk can be identified before clinical or biochemical signs of the disease become evident. METHODS Twenty-one families with MEN 2 (16 families with MEN 2A and 5 families with MEN 2B) were… CONTINUE READING

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