Very Low-Density Lipoprotein Activates Nuclear Factor-k B in Endothelial Cells

@inproceedings{Dichtl1999VeryLL,
  title={Very Low-Density Lipoprotein Activates Nuclear Factor-k B in Endothelial Cells},
  author={Wolfgang Dichtl and Lennart Nilsson and Isabel Goncalves and Mikko P. S. Ares and Cristina Banfi and Federico Calara and Anders Hamsten and Per Eriksson and Jan Nilsson},
  year={1999}
}
High plasma levels of VLDL are associated with increased risk for atherosclerosis. Here we show that VLDL (75 to 150mg/mL) activates nuclear factorkB (NF-kB), a transcription factor known to play a key role in regulation of inflammation. Oxidation of VLDL reduced its capacity to activate NFkB in vitro, whereas free fatty acids such as linoleic and oleic acid activated NFkB to the same extent as did VLDL. Intravenous injection of human VLDL (6 mg protein per kg) into rats resulted in arterial… CONTINUE READING
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