Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced

Abstract

To understand the relationship between the affinity of the B cell antigen receptor (BCR) and the immune response to antigen, two lines of immunoglobulin H chain transgenic (Tg) mice were created. H50Gmu(a) and T1(V23)mu(a) mice express mu H chain transgenes that associate with the lambda1 L chains to bind the (4-hydroxy-3-nitrophenyl)acetyl hapten with… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Porto2002VeryLA, title={Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced}, author={Joseph M. Dal Porto and Ann M. Haberman and Garnett H. Kelsoe and Mark J. Shlomchik}, journal={The Journal of Experimental Medicine}, year={2002}, volume={195}, pages={1215 - 1221} }