Vertigo and vestibular abnormalities in spinocerebellar ataxia type 6

@article{YuWaiMan2009VertigoAV,
  title={Vertigo and vestibular abnormalities in spinocerebellar ataxia type 6},
  author={Patrick Yu-Wai-Man and Grainne M Gorman and David E. Bateman and R. John Leigh and Patrick F. Chinnery},
  journal={Journal of Neurology},
  year={2009},
  volume={256},
  pages={78-82}
}
Spinocerebellar ataxia type 6 (SCA6) is a calcium channelopathy due to a pathological CAG repeat expansion in CACNL1A4. Patients frequently describe paroxysmal vertigo early in the disease course, but it is not clear whether this is central or labyrinthine in origin. To address this issue we studied 21 SCA6 patients. Symptoms of vertigo were defined using a structured questionnaire. Signs were recorded during a standardised bed-side vestibular examination that included systematic positional… CONTINUE READING