Vertigo and Motion Sickness. Part II: Pharmacologic Treatment

@article{Zajonc2006VertigoAM,
  title={Vertigo and Motion Sickness. Part II: Pharmacologic Treatment},
  author={Timothy P Zajonc and Peter Sargent Roland},
  journal={ENT Journal},
  year={2006},
  volume={85},
  pages={25 - 35}
}
Vertigo is a sensation of movement when no movement is actually occurring. It is often accompanied by visceral autonomic symptoms including pallor, diaphoresis, nausea, and vomiting. Vertigo is similar to motion sickness in that both may be caused by vestibular stimulation that does not match an internal model of expected environmental stimuli. Indeed, a functioning vestibular system is necessary for the perception of motion sickness. For this reason, many of the same drugs are used to treat… 

Tables from this paper

The Neurophysiology and Treatment of Motion Sickness.
TLDR
The various types of motion sickness can be treated with general measures to lessen the intersensory conflict, behavioral changes, and drugs.
Prevention and treatment of motion sickness.
TLDR
Patients should learn to identify situations that will lead to motion sickness and minimize the amount of unpleasant motion they are exposed to by avoiding difficult conditions while traveling or by positioning themselves in the most stable part of the vehicle.
Motion sickness in children and adolescents: pathogenesis, symptoms, profylaxis and treatment (literature review)
TLDR
There are presented data concerning terminology, pathogenesis, semiology, (complaints, signs), prevention and management of symptom complex of motion sickness and kinetosis, and the importance and possibilities of the solution of this problem in pediatric practice.
Meclizine: Safety and Efficacy in the Treatment and Prevention of Motion Sickness
TLDR
Meclizine is a piperzine antihistamine that is effective for the prevention and treatment of motion sickness, particularly during mild civilian travel.
Principles of vestibular pharmacotherapy.
  • C. Chabbert
  • Medicine, Biology
    Handbook of clinical neurology
  • 2016
Verification of Motion Sickness Index in Mice
TLDR
The results demonstrated that similar to the sensitivity of pica to vestibular system damage [8], the criteria is sensitive to bilateral labyrinthectomy and suitable to evaluated antimotion sickness drugs.
Galvanic vestibular stimulation: a novel modulatory countermeasure for vestibular-associated movement disorders.
TLDR
Galvanic vestibular stimulation has the potential of up-regulating disturbed sensory-motor mismatch originated by kinetosis and space sickness by modulating the GABA-related ion channels neural transmission in the inner ear.
Vomiting Reflex Components , Receptors , and Controlling Neurotransmitters and Medications
TLDR
The history obtained from the client should be as detailed as possible because historical details are often helpful in selecting the appropriate treatment and diagnostic plan.
Neuropharmacology of Vestibular System Disorders
TLDR
Drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels.
...
1
2
3
4
...

References

SHOWING 1-10 OF 110 REFERENCES
Diazepam as an anti-motion sickness drug.
TLDR
Motion sickness endpoints were measured subjectively using a nausea scale and objectively using a sweat sensor and the results showed significant antimotion sickness properties for both dimenhydrinate and diazepam as compared to the placebo.
Flunarizine in the Treatment of Vestibular Vertigo: Experimental and Clinical Data
TLDR
Clinical trials versus placebo and reference drugs proved flunarizine to be effective in the treatment of vestibular disorders and its mechanism of action was confirmed to be calcium-entry blockade.
Lack of effects of astemizole on vestibular ocular reflex, motion sickness, and cognitive performance in man.
TLDR
It is concluded that, although the drug probably reaches the peripheral vestibular apparatus in man by crossing the blood-vestibular barrier, a selective peripheral antihistamine (H1) action is inadequate to control motion sickness induced through cross-coupled accelerative semicircular canal stimulation in a rotating chair.
Calcium antagonists in the prevention of motion sickness.
TLDR
Flunarizine is shown to be a powerful peripherally acting labyrinthine suppressant, with application in the prevention of motion sickness.
Use of Promethazine to Hasten Adaptation to Provocative Motion
TLDR
This study controlled arousal using a mental arithmetic task and precisely equated the exposure history of a placebo, control group and an experimental group who had received promethazine to suggest a strategy for dealing with space motion sickness.
Vertigo and Motion Sickness. Part I: Vestibular Anatomy and Physiology
Control of the symptoms of vertigo and motion sickness requires consideration of the neurophysiology of areas both intrinsic and extrinsic to the vestibular system proper. We review the essential
Antivertigo medications and drug-induced vertigo. A pharmacological review.
TLDR
It is hoped that new treatments may emerge from the present interest in receptor subclasses and neuromodulators of the vestibular system, and the authors must be ready to evaluate these potential new pharmacological agents with reliable clinical methods in humans.
Use of phenytoin in the prevention of motion sickness.
TLDR
A placebo-controlled double-blind crossover pilot study of acute Coriolis-induced motion sickness treatment/prevention in humans employing an anticonvulsant dose of phenytoin shows a greater than fourfold improvement in efficacy over any currently available single agent and is more than twice as effective as the scopolamine/dexadrine combination.
Effects of phenytoin on vection-induced motion sickness and gastric myoelectric activity.
TLDR
It is demonstrated that a single low dose of phenytoin prevents the development of gastric tachyarrhythmia and decreases the intensity of motion sickness symptoms.
...
1
2
3
4
5
...