Vertical human immunodeficiency virus type 1--HIV-1--transmission--a review.

  title={Vertical human immunodeficiency virus type 1--HIV-1--transmission--a review.},
  author={Vera Bongertz},
  journal={Memorias do Instituto Oswaldo Cruz},
  volume={96 1},
  • V. Bongertz
  • Published 2001
  • Medicine
  • Memorias do Instituto Oswaldo Cruz
Several factors appear to affect vertical HIV-1 transmission, dependent mainly on characteristics of the mother (extent of immunodeficiency, co-infections, risk behaviour, nutritional status, immune response, genetical make-up), but also of the virus (phenotype, tropism) and, possibly, of the child (genetical make-up). This complex situation is compounded by the fact that the virus may have the whole gestation period, apart from variable periods between membrane rupture and birth and the breast… 

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