Vertebrate homeobox gene nomenclature

@article{Scott1992VertebrateHG,
  title={Vertebrate homeobox gene nomenclature},
  author={Matthew P Scott},
  journal={Cell},
  year={1992},
  volume={71},
  pages={551-553}
}
  • M. Scott
  • Published 13 November 1992
  • Medicine, Biology
  • Cell
Seven Hox gene sequences from the asterinid starfish Patiriella exigua (Echinodermata: Asteroidea)
Partial homeobox gene fragments were amplified from Patiriella exigua genomic DNA by PCR using degenerate primers. The primers spanned a region of 82 nucleotides within the homeobox, encompassingExpand
Seven Hox genes sequences from the asterinid starfish Patiriella exigua (Echinodermata: Asteroidea)
TLDR
Partial homeobox gene fragments were amplified from Patiriella exigua genomic DNA by PCR using degenerate primers, and the deduced amino acid sequences of the seven Hox gene sequences plus one Xlox-type gene sequence from P.Exigua are presented and compared with similar sequences from other organisms. Expand
cDNA cloning and partial sequencing of homeobox genes in Dugesia japonica
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The cloning and sequencing of 31 homeobox (HB) sequences are reported, identified using degenerate oligodeoxyribonucleotide primers, in a polymerase chain reaction with cDNA derived from a purified CD34+ population of human haemopoietic cells. Expand
A high-throughput method for monitoring changes in homeobox gene expression.
TLDR
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It is considered that replacement of vertebrates by invertebrates in ecotoxicity testing is likely to become a reality when basic knowledge of metabolic, physiologic, and developmental patterns in the latter will be sufficient to assess the effect of a given chemical through end points that could be different between invertebrate and vertebrates. Expand
Genomic resources for the study of sea urchin development.
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Developmental Effects of Toxic Doses of Iodine
This chapter summarizes the previous evidence and presents the major advances of developmental toxic effects induced by excess iodine in animals and humans. Adequate iodine intake is indispensable toExpand
Molecular control of development in the reef coral, Acropora millepora
TLDR
The evolutionary approach that the Cnidaria are taking to the characterisation of coral genes is illustrated with a review of their work on the Acropora Hox- like gene, cnox2-Am. Expand
Homeobox gene expression in ovarian cancer.
TLDR
The effects of vertebrate HOX genes can be ascertained from their expression pattern during mouse development and from the phenotype of mice with a targeted deletion, disruption or overexpression of a specific Hox gene. Expand
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References

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TLDR
Recent data obtained from embryonal carcinoma cells induced to differentiate by retinoic acid cast some light on the molecular mechanisms underlying the collinear expression of the Hox genes. Expand
Genes and Developmental Pathways
TLDR
An approach is discussed which makes use of a series of pseudoallelic genes in Drosophila which have, in several instances, been profitably exploited in the bacteria to learn more about how genes control biochemical pathways. Expand
Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice
TLDR
The generated transgenic mice that ectopically express Hox-1.1 suggest that retinoic acid embryopathy and the specific developmental defects caused by ectopic expression of a potential developmental control gene share a common pathogenic mechanism. Expand
Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene
TLDR
The Hox-3.1 coding sequence was replaced with the E. coli lacZ gene by means of homologous recombination in embryonic stem cells and thus produced null mutant mice and several skeletal segments were transformed into the likeness of more anterior ones, as observed in Drosophila with loss-of-function homeotic mutations. Expand
Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development
TLDR
A construct carrying the mouse Hox-1.4 gene was introduced into the germ line of mice to begin to identify the m-acting elements required for proper expression and to assess the consequences of increasing Hox -1. Expand
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TLDR
Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox, paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. Expand
Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae
TLDR
It is found that one of the mouse Antp-like genes, Hox-2.2, when expressed in developing Drosophila cells under control of a heat shock promoter, can induce homeotic transformations that are nearly identical to those caused by ectopic expression of Antp. Expand
The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.
TLDR
The cloning of the fourth major murine homeogene complex, HOX‐5.3, shows that the expression of murine Antp‐like homeobox‐containing genes along the antero‐posterior developing body axis follows a positional hierarchy which reflects their respective physical positions within the HOX clusters, similar to that which is found for the Drosophila homeotic genes. Expand
The murine and Drosophila homeobox gene complexes have common features of organization and expression
TLDR
Alignment shows a clear relationship among genes in the mouse and Drosophila complexes, based on relative position, sequence identity, and domains of expression along the rostral-caudal axis. Expand
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
TLDR
Within the same region of the presumptive hindbrain, two HOX-1 genes are involved in the patterning of two different populations of neural crest cells, and the implication of these results for the function of the Hox network during mouse embryogenesis is discussed. Expand
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