Vertebrate gene finding from multiple-species alignments using a two-level strategy

  title={Vertebrate gene finding from multiple-species alignments using a two-level strategy},
  author={David M. Carter and Richard Durbin},
  journal={Genome Biology},
  pages={S6 - S6}
One way in which the accuracy of gene structure prediction in vertebrate DNA sequences can be improved is by analyzing alignments with multiple related species, since functional regions of genes tend to be more conserved. We describe DOGFISH, a vertebrate gene finder consisting of a cleanly separated site classifier and structure predictor. The classifier scores potential splice sites and other features, using sequence alignments between multiple vertebrate species, while the structure… CONTINUE READING

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