Vertebrate Smoothened functions at the primary cilium

@article{Corbit2005VertebrateSF,
  title={Vertebrate Smoothened functions at the primary cilium},
  author={Kevin C. Corbit and Pia Aanstad and Veena Singla and Andrew R. Norman and Didier Y R Stainier and Jeremy F Reiter},
  journal={Nature},
  year={2005},
  volume={437},
  pages={1018-1021}
}
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal transduction. Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium. This ciliary expression is regulated by Hh pathway activity; Sonic hedgehog or activating mutations in Smo promote ciliary localization, whereas the Smo antagonist… CONTINUE READING

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