Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

@inproceedings{Leo2015VertebrateFR,
  title={Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules},
  author={Lanfranco Leo and Wenqian Yu and Mitchell D’Rozario and Edward A. Waddell and Daniel Marenda and Michelle A. Baird and Michael W. Davidson and Bin Zhou and Bingro Wu and Lisa Baker and David J. Sharp and Peter W. Baas},
  booktitle={Cell reports},
  year={2015}
}
Individual microtubules (MTs) in the axon consist of a stable domain that is highly acetylated and a labile domain that is not. Traditional MT-severing proteins preferentially cut the MT in the stable domain. In Drosophila, fidgetin behaves in this fashion, with targeted knockdown resulting in neurons with a higher fraction of acetylated (stable) MT mass in their axons. Conversely, in a fidgetin knockout mouse, the fraction of MT mass that is acetylated is lower than in the control animal. When… CONTINUE READING
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