Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases.

@article{Lewandrowski2007VertebralOA,
  title={Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases.},
  author={K. U. Lewandrowski and Christopher J Nanson and Robert H. Calderon},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2007},
  volume={7 5},
  pages={609-14}
}
BACKGROUND Recombinant human bone morphogenetic protein 2 (rh-BMP-2) is frequently used in an off-label fashion. Its application for posterior interbody fusion appears intuitive because its use obviates the need for iliac crest bone graft and shows higher fusion rates than with the use of local autologous bone graft. To date, there is no report of adverse outcomes with such use of rh-BMP-2. PURPOSE To draw attention to this unusual complication of posterior interbody lumbar fusion and to… CONTINUE READING

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