Vertebral fracture or vertebral deformity?

  title={Vertebral fracture or vertebral deformity?},
  author={Michael Kleerekoper and Dorothy A. Nelson},
  journal={Calcified Tissue International},
In our recently completed sodium fluoride (NaF) clinical trial [1] we observed that only about 25% of vertebral deformities, documented by change in vertebral morphometry on radiographs, were associated with corresponding areas of increased isotope uptake on radionuclide bone scans. This was an unexpected finding. In the initial trial design, we had anticipated that the scan would be more sensitive than radiographs and would detect "fractures" that were not documented radiographically. The… CONTINUE READING