Versican and brevican are expressed with distinct pathology in neonatal hypoxic‐ischemic injury

  title={Versican and brevican are expressed with distinct pathology in neonatal hypoxic‐ischemic injury},
  author={C. Leonardo and Autumn K. Eakin and Joanne M. Ajmo and P. Gottschall},
  journal={Journal of Neuroscience Research},
  • C. Leonardo, Autumn K. Eakin, +1 author P. Gottschall
  • Published 2008
  • Biology, Medicine
  • Journal of Neuroscience Research
  • The developing brain is uniquely susceptible to injury after exposure to hypoxia‐ischemia (H‐I). Lecticans are developmentally regulated in formative white matter and exert growth‐inhibitory effects in several adult injury models, yet little is known regarding their role in neonatal H‐I injury. The main objectives of this study were to examine the expression profiles of brevican and versican in rat using a standard H‐I model and to determine whether altered expression was associated with… CONTINUE READING
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