Versican V1 isoform regulates cell-associated matrix formation and cell behavior differentially from aggrecan in Swarm rat chondrosarcoma cells.

@article{Wasa2012VersicanVI,
  title={Versican V1 isoform regulates cell-associated matrix formation and cell behavior differentially from aggrecan in Swarm rat chondrosarcoma cells.},
  author={Junji Wasa and Yoshihiro Nishida and Tamayuki Shinomura and Zenzo Isogai and Naohisa Futamura and Hiroshi Urakawa and Eisuke Arai and Eiji Kozawa and Satoshi Tsukushi and Naoki Ishiguro},
  journal={International journal of cancer},
  year={2012},
  volume={130 10},
  pages={2271-81}
}
Versican, a large chondroitin sulfate proteoglycan that binds hyaluronan and is composed of large extracellular matrix aggregates, has been shown to correlate with tumor progression. No studies have examined the roles of versican in chondrosarcoma nor compared them to those of aggrecan. In clinical specimens of human chondromatous tumors, versican expression was significantly increased in malignant tumors, moreover, as the tumor grade increased. To clarify the roles of versican in… CONTINUE READING