Versatile synthesis of isocoumarins and α-pyrones by ruthenium-catalyzed oxidative C-H/O-H bond cleavages.

@article{Ackermann2012VersatileSO,
  title={Versatile synthesis of isocoumarins and α-pyrones by ruthenium-catalyzed oxidative C-H/O-H bond cleavages.},
  author={Lutz Ackermann and Jola Pospech and Karolina Graczyk and Karsten Rauch},
  journal={Organic letters},
  year={2012},
  volume={14 3},
  pages={930-3}
}
An inexpensive cationic ruthenium(II) catalyst enabled the expedient synthesis of isocoumarins through oxidative annulations of alkynes by benzoic acids. This C-H/O-H bond functionalization process also proved applicable to the preparation of α-pyrones and was shown to proceed by rate-limiting C-H bond ruthenation.