Versatile substrate protein recognition mechanism of the eukaryotic chaperonin CCT.

Abstract

Group II chaperonins, found in eukaryotic and archaeal organisms, recognize substrate proteins through diverse mechanisms that involve either hydrophobic- or electrostatic-dominated interactions. This action is distinct from the universal substrate recognition mechanism of group I chaperonins, which bind a wide spectrum of non-native proteins primarily… (More)
DOI: 10.1002/prot.22644

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