Versatile effects of aurone structure on mushroom tyrosinase activity.

@article{Dubois2012VersatileEO,
  title={Versatile effects of aurone structure on mushroom tyrosinase activity.},
  author={Carole Dubois and Romain Haudecoeur and Maylis Orio and Catherine Belle and Constance Bochot and Ahc{\`e}ne Boumendjel and Renaud Hardr{\'e} and H{\'e}lene Jamet and Marius R{\'e}glier},
  journal={Chembiochem : a European journal of chemical biology},
  year={2012},
  volume={13 4},
  pages={559-65}
}
Elucidation of the binding modes of Ty inhibitors is an important step for in-depth studies on how to regulate tyrosinase activity. In this paper we highlight the extraordinarily versatile effects of the aurone structure on mushroom Ty activity. Depending on the position of the OH group on the B-ring, aurones can behave either as substrates or as hyperbolic activators. The synthesis of a hybrid aurone through combination of an aurone moiety with HOPNO (2-hydroxypyridine N-oxide), a good metal… CONTINUE READING
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