Versatile Structures of α-Synuclein

  title={Versatile Structures of α-Synuclein},
  author={Chuchu Wang and Chunyu Zhao and Dan Li and Zhiqi Tian and Ying Lai and Jiajie Diao and Cong Liu},
  booktitle={Front. Mol. Neurosci.},
α-Synuclein (α-syn) is an intrinsically disordered protein abundantly distributed in presynaptic terminals. Aggregation of α-syn into Lewy bodies (LB) is a molecular hallmark of Parkinson's disease (PD). α-Syn features an extreme conformational diversity, which adapts to different conditions and fulfills versatile functions. However, the molecular mechanism of α-syn transformation and the relation between different structural species and their functional and pathogenic roles in neuronal… CONTINUE READING
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