Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells.

@article{Lee2016VerprosideIT,
  title={Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells.},
  author={Su Ui Lee and Min Hee Sung and Hyung Won Ryu and Jinhyuk Lee and Hui-Seong Kim and Hyun Ju In and Kyung-Seop Ahn and Hyun-Jun Lee and Hyeong-Kyu Lee and Dae-Hee Shin and Yongnam Lee and Sung Tae Hong and Sei-Ryang Oh},
  journal={Cytokine},
  year={2016},
  volume={77},
  pages={
          168-75
        }
}
Airway mucus secretion is an essential innate immune response for host protection. However, overproduction and hypersecretion of mucus, mainly composed of MUC5AC, are significant risk factors in asthma and chronic obstructive pulmonary disease (COPD) patients. Previously, we reported that verproside, a catalpol derivative iridoid glycoside isolated from Pseudolysimachion rotundum var. subintegrum, is a potent anti-asthmatic candidate drug in vivo. However, the molecular mechanisms underlying… CONTINUE READING

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Piscroside C inhibits TNF-α/NF-κB pathway by the suppression of PKCδ activity for TNF-RSC formation in human airway epithelial cells.

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