Vermiculite Worker Mortality: Estimated Effects of Occupational Exposure to Libby Amphibole

@article{Larson2010VermiculiteWM,
  title={Vermiculite Worker Mortality: Estimated Effects of Occupational Exposure to Libby Amphibole},
  author={Theodore Larson and Vinicius C Antao and Frank James Bov{\'e}},
  journal={Journal of Occupational and Environmental Medicine},
  year={2010},
  volume={52},
  pages={555-560}
}
Objective: To examine the relationship between cumulative fiber exposure (CFE) and mortality in a retrospective cohort study of vermiculite workers exposed to Libby amphibole (n = 1862). Methods: Extended Cox regression was used to estimate the hazards associated with CFE as a time-dependent covariate of multiple-cause mortality. Results: The Cox models for mesothelioma, asbestosis, lung cancer, and non-malignant respiratory disease were significant with rate ratios that increased monotonically… 

Mesothelioma Associated With Commercial Use of Vermiculite Containing Libby Amphibole

TLDR
Workers expanding and processing Libby vermiculite in a manufacturing setting demonstrated an increased risk for the development of mesothelioma following exposure to the amphibole fiber contained within this verMiculite ore source.

Mortality from asbestos-associated disease in Libby, Montana 1979–2011

TLDR
The results suggest that the general population may be experiencing asbestos-related effects, not just former vermiculite workers, and additional research is needed to determine whether SMRs remain elevated after controlling for secondary exposure, such as living with vermicULite workers.

LUNG CANCER MORTALITY RISK AMONG AN OCCUPATIONAL COHORT EXPOSED TO A MIXTURE OF COMMERCIAL AND NON-COMMERCIAL AMPHIBOLE ASBESTOS FROM VERMICULITE MINING OPERATIONS IN LIBBY, MONTANA

TLDR
Libby amphibole asbestos, a mixture composed primarily of non-commercial amphiboles asbestos, has repeatedly been shown to be associated with lung cancer mortality by different investigators using varying definitions of this occupational cohort.

Comparative health e ff ects in mice of Libby amphibole asbestos and a fi brous amphibole from Arizona

TLDR
Comparisons of health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses suggest there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana.

Multiple pathway asbestos exposure assessment for a Superfund community

TLDR
A comprehensive exposure assessment approach is developed that integrates information on individuals’ contact frequency with multiple exposure pathways and will advance health studies and risk assessment approaches in this population with a complex history of both occupational and environmental asbestos exposure.

Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona

Vascular and Thrombogenic Effects of Pulmonary Exposure to Libby Amphibole

TLDR
Exposure to Libby amphibole (LA) asbestos decreased circulating platelets and platelet coagulability while increasing the expression of oxidative stress, thrombosis, and vasoconstriction biomarkers in the aorta of healthy rats, suggestingThrombogenic, vasocontractile, and oxidative stress-mediated impairments.

Sumas Mountain chrysotile induces greater lung fibrosis in Fischer344 rats than Libby amphibole, El Dorado tremolite, and Ontario ferroactinolite.

TLDR
It is demonstrated that fiber length and higher AR are directly correlated with the severity of fibrosis and that, in the rat, exposure to SM is more fibrogenic than LA which suggests that there may be cause for concern for people at risk of being exposed to NOA from the Sumas Mountain landslide.

Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure

TLDR
Pleural cancer rate increased during the first 40 years of TSFE and reached a plateau after and was confirmed for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract.

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