Verification of the causal relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice

  title={Verification of the causal relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice},
  author={Tadashi Takada and Naoki Yoneda and Tetsushi Hirano and Shogo Yanai and Anzu Yamamoto and Youhei Mantani and Toshifumi Yokoyama and Hiroshi Kitagawa and Yoshiaki Tabuchi and Nobuhiko Hoshi},
  journal={The Journal of Veterinary Medical Science},
  pages={720 - 724}
It has been suggested that an increase in the use of pesticides affects neurodevelopment, but there has been no animal experiment showing a causal relation between neonicotinoid pesticides (NNs) and depression. We examined whether dinotefuran (DIN), the most widely used NN in Japan, induces depression. Male mice were administered DIN between 3 and 8 weeks of age, referring to the no-observed-effect level (NOEL). The mice were then subjected to a tail suspension test (TST) and a forced swimming… 

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