Verification of exposure to cholinesterase inhibitors: generic detection of OPCW Schedule 1 nerve agent adducts to human butyrylcholinesterase.

@article{Schans2008VerificationOE,
  title={Verification of exposure to cholinesterase inhibitors: generic detection of OPCW Schedule 1 nerve agent adducts to human butyrylcholinesterase.},
  author={Marcel J. van der Schans and Alex Fidder and D van Oeveren and Albert G. Hulst and Daan Noort},
  journal={Journal of analytical toxicology},
  year={2008},
  volume={32 1},
  pages={
          125-30
        }
}
Phosphylated butyrylcholinesterase is one of the most important biomarkers to verify an exposure to nerve agents, and it can be analyzed with liquid chromatography-tandem mass spectrometry (LC-MS-MS) by detection of a phosphylated nonapeptide that results after digestion of butyrylcholinesterase (BuChE) with pepsin. For a sensitive analysis (low degree of BuChE inhibition), the identity of the cholinesterase inhibitor has to be known in order to use the LC-MS-MS instrument in the most sensitive… CONTINUE READING
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