Verification of a new model of the time course of RNA synthesis. Measurement of the rates of initiation and elongation.


The time course of RNA synthesis in vitro commonly starts with a lag followed by a linear phase. Differing from the earlier interpretation we have previously proposed that, under conditions where the initiation rate is low, the lag represents the time taken for the first RNA polymerase molecule to reach a termination site. During the linear phase… (More)


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