Verbal memory impairment correlates with hippocampal pyramidal cell density

@article{Sass1990VerbalMI,
  title={Verbal memory impairment correlates with hippocampal pyramidal cell density},
  author={Kimberlee J. Sass and Dennis D. Spencer and Jung Hwa Kim and Michael Westerveld and Robert A. Novelly and Todd Lencz},
  journal={Neurology},
  year={1990},
  volume={40},
  pages={1694 - 1694}
}
Thirty-five patients with medically refractory epilepsy localized to the temporal lobe (18 left, 17 right) completed the verbal Selective Reminding Test before surgery. Verbal memory impairments existed before surgery regardless of the lateralization of the seizure focus, but patients with left temporal seizure foci were significantly more impaired. After surgical removal of the mesial temporal lobe structures, 2 blinded observers established volumetric cell densities for hippocampal subfields… Expand
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The results suggest that the overall pathological status of the left hippocampus – rather than a specific subfield pathology – is predictive for verbal memory in mTle, and the finding that figural memory parameters, although sensitive to right mTLE, were not related to neuronal cell densities of the right hippocampus, puts the left/right hippocampus verbal/nonverbal memory dichotomy into perspective. Expand
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This study hypothesized that verbal memory decline following anterior temporal lobectomy (ATL) is associated with a lack of significant neuropathology in resected left, but not right, hippocampus andExpand
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Findings support a role for the left hippocampus in rote verbal memory, ie, learning of unrelated word pairs in patients with left but not right temporal lobe seizures, and patients with severe loss of left hippocampal neurons may be at risk for lower memory functioning postoperatively. Expand
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Anterior temporal lobectomy (ATL) is an effective and increasingly utilized treatment for nonlesional, intractable mesial temporal lobe epilepsy. However, this surgery results in domain-specificExpand
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The degree of hippocampal neuron loss determines to a great extent the severity of the verbal memory decrease that follows dominant anteromesiotemporal lobectomy. Expand
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