Veratridine actions on two types of fast Na+ channels in human uterine leiomyosarcoma cells.

@article{Kusaka1994VeratridineAO,
  title={Veratridine actions on two types of fast Na+ channels in human uterine leiomyosarcoma cells.},
  author={Masatomo Kusaka and Nick Sperelakis},
  journal={European journal of pharmacology},
  year={1994},
  volume={271 2-3},
  pages={387-93}
}
In human uterine leiomyosarcoma cell line (SK-UT-1B), we previously demonstrated two types of fast Na+ current (INa(f)) induced by serum, based on different time course of current decay: fast-inactivating and slow-inactivating. To further clarify the properties of these currents, we studied the effects of veratridine, which is known to modify the inactivation process of INa(f), using whole-cell voltage clamp. Bath application of veratridine (100 microM) produced a decrease in peak INa(f) (Ipeak… CONTINUE READING

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