Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance.

  title={Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance.},
  author={Bernard W. Futscher and N E Foley and Mary C Gleason-Guzman and Paul S. Meltzer and Dan M. Sullivan and William S Dalton},
  journal={International journal of cancer},
  volume={66 4},
Selection protocols were designed to determine whether non-cytotoxic chemomodifiers can influence the evolution of the drug-resistant phenotype. To this end, the human multiple myeloma cell line RPMI 8226 (8226/S) was selected with either doxorubicin, verapamil or doxorubicin plus verapamil. Using this approach low-level multi-drug-resistant (MDR) cell lines were obtained when 8226/S was selected with doxorubicin only or doxorubicin plus verapamil but not with verapamil only. The MDR phenotypes… CONTINUE READING

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