Verapamil-induced contracture in an excised, blood-perfused skeletal muscle preparation from the dog.

@article{Sato1983VerapamilinducedCI,
  title={Verapamil-induced contracture in an excised, blood-perfused skeletal muscle preparation from the dog.},
  author={Takumi Sato and Kenji Suzuki and Takuma Aoyama and Hiroyuki Ono},
  journal={Clinical and experimental pharmacology & physiology},
  year={1983},
  volume={10 5},
  pages={505-9}
}
The ability of verapamil to induce a contractile response in skeletal muscle was investigated using the canine isolated, blood-perfused diaphragm preparation. Verapamil-induced contracture was characterized by a biphasic increase in muscle tension consisting of an initial phasic and subsequent tonic contracture. The second tonic component of the verapamil… CONTINUE READING