Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis.

Abstract

Drug efflux pumps play important roles in intrinsic and acquired drug resistance. Verapamil, an efflux inhibitor that enhances the activity of bedaquiline, clofazimine, and other drugs against Mycobacterium tuberculosis, has been proposed as a potential adjunctive agent for treatment of tuberculosis (TB). However, the extent to which verapamil enhances in… (More)
DOI: 10.1128/AAC.01692-17

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Cite this paper

@article{Xu2018VerapamilIT, title={Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis.}, author={Jian-guo Xu and Rokeya Tasneen and C A Charles A Peloquin and Deepak V. Almeida and Si-yang Li and Kala Barnes-Boyle and Yu Lu and Eric L. Nuermberger}, journal={Antimicrobial agents and chemotherapy}, year={2018}, volume={62 1} }