Ventx Factors Function as Nanog-Like Guardians of Developmental Potential in Xenopus

  title={Ventx Factors Function as Nanog-Like Guardians of Developmental Potential in Xenopus},
  author={Pierluigi Scerbo and Fabrice Girardot and C{\'e}line Vivien and Gabriel V. Markov and Guillaume Luxardi and Barbara A Demeneix and Laurent Kodjabachian and Laurent Coen},
  booktitle={PloS one},
Vertebrate development requires progressive commitment of embryonic cells into specific lineages through a continuum of signals that play off differentiation versus multipotency. In mammals, Nanog is a key transcription factor that maintains cellular pluripotency by controlling competence to respond to differentiation cues. Nanog orthologs are known in most vertebrates examined to date, but absent from the Anuran amphibian Xenopus. Interestingly, in silico analyses and literature scanning… CONTINUE READING
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