Ventromedial prefrontal cortex processing during emotional evaluation in late-life depression: a longitudinal functional magnetic resonance imaging study.

@article{Brassen2008VentromedialPC,
  title={Ventromedial prefrontal cortex processing during emotional evaluation in late-life depression: a longitudinal functional magnetic resonance imaging study.},
  author={Stefanie Brassen and Raffael Kalisch and Wolfgang Weber-Fahr and Dieter F. Braus and Christian B{\"u}chel},
  journal={Biological psychiatry},
  year={2008},
  volume={64 4},
  pages={349-55}
}
BACKGROUND Functional imaging studies using emotional stimuli have suggested a role for the ventromedial prefrontal cortex (vmPFC) in the pathophysiology of midlife depression. In contrast, the neural correlates of late-life depression (LLD), a highly prevalent but under-recognized clinical entity in which age-related brain changes might influence disease mechanisms, have not been studied in great detail. With an emotional evaluation task, we conducted a longitudinal study of vmPFC functioning… CONTINUE READING