Ventromedial prefrontal cortex mediates guessing

  title={Ventromedial prefrontal cortex mediates guessing},
  author={Rebecca Elliott and Geraint Rees and R. J. Dolan},

Figures and Tables from this paper

Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies.

It is suggested that selection of stimuli on the based of their familiarity and responses on the basis of a feeling of 'rightness' are also examples of selection on theBased of reward value, the lateral regions are more likely to be involved when the action selected requires the suppression of previously rewarded responses.

Distinct roles of prefrontal cortical subregions in the Iowa Gambling Task.

A version of the Iowa Gambling Task specifically modified for event-related functional magnetic resonance imaging is developed and validated, revealing that deciding advantageously under initially ambiguous conditions may require both continuous and dynamic processes involving both the ventral and dorsal prefrontal cortex.

The Neural Substrate of Orientation Working Memory

The current findings confirm the distinction between maintenance and manipulative processes, highlight the functional heterogeneity in the prefrontal cortex (PFC), and suggest a more dynamic view of WM as a process requiring the coordinated interaction of anatomically distinct brain areas.

Sequential Involvement of Distinct Portions of the Medial Prefrontal Cortex in Different Stages of Decision Making Using the Iowa Gambling Task

These findings suggest that cognitive division of the mPFC, including the dorsal portion of the anterior cingulated cortex (ACC), plays a major role in ambiguous decision making and that the aspect of the IGT corresponding to risky decision making is associated with significant activity within the corticolimbic network strongly implicated in emotion and reinforcement.

Behavioral and Functional Neuroimaging Evidence for Prefrontal Dysfunction in Methamphetamine-Dependent Subjects

Contributions of the prefrontal cortex to the neural basis of human decision making

Brain activations associated with shifts in response criterion on a recognition test.

The results indicated that activations associated with shifting criteria (a manipulation of bias) were located in bilateral regions of the lateral cerebellum, lateral parietal lobe, and the dorsolateral prefrontal cortex extending from the supplementary motor area.



Dissociation in prefrontal cortex of affective and attentional shifts

It is demonstrated that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory Control in different aspects of cognitive processing.

Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex

A cognitive and anatomic double dissociation between deficits in decision making (anterior VM) and working memory (right DL/M) is revealed, the first direct evidence of such effects in humans using the lesion method and underscores the special importance of the VM prefrontal region in decisionMaking, independent of a direct role in working memory.

Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans

Findings further implicate frontostriatal circuitry in high‐level planning and provide evidence for functionally distinct contributions from ventral and dorsolateral frontal regions to spatial working memory.

Functional activation of the human frontal cortex during the performance of verbal working memory tasks.

Evidence is provided regarding the role of the mid-dorsolateral frontal cortex in mnemonic processing that are in agreement with recent findings from work with non-human primates.

"Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task.

A clear separation of activation foci in the left dorsolateral prefrontal cortex for the sensorimotor and verbal fluency tasks is found and assigning a particular activated region to "willed action" is not supported by the fMRI data when examined closely because identical regions are not activated with different modalities.

Regional brain activity during working memory tasks.

The data confirm that the lower left supramarginal gyrus and premotor area are the key regions subserving short-term verbal memory processes and suggest that the updating memory task is related to middorsolateral prefrontal activation, most probably responsible for the updating function of the central executive.

A positron emission tomography study of the short-term maintenance of verbal information

Based on converging results in this and previous studies, dorsolateral prefrontal cortical areas appear to contribute to the maintenance of both verbal and nonverbal information, whereas left frontal opercular regions appear to be involved specifically in the rehearsal of verbal material.