Ventromedial hypothalamus suppresses splenic lymphocyte activity through sympathetic innervation.

@article{Okamoto1996VentromedialHS,
  title={Ventromedial hypothalamus suppresses splenic lymphocyte activity through sympathetic innervation.},
  author={Shinobu Okamoto and Kyoko Ibaraki and Shinji Hayashi and Mitsuru Saito},
  journal={Brain research},
  year={1996},
  volume={739 1-2},
  pages={308-13}
}
The ventromedial hypothalamic nucleus (VMH) has been proposed to be a locus intimately associated with sympathetic facilitation in peripheral tissues. To investigate a possible role of the VMH in controlling peripheral immune functions, we examined the effects of VMH stimulation on proliferative activity of lymphocytes isolated from the spleen in rats. Electrical stimulation of the VMH (2 s at every 30 s for 30 min) caused a remarkable decrease in the mitogenic response of splenic lymphocytes… CONTINUE READING