Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II.

@article{Muratani1993VentrolateralMI,
  title={Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II.},
  author={Hiroshi Muratani and Carlos Maria Ferrario and David B. Averill},
  journal={The American journal of physiology},
  year={1993},
  volume={264 2 Pt 2},
  pages={R388-95}
}
We investigated whether angiotensin II (ANG II), endogenous to the ventrolateral medulla (VLM), contributes to cardiovascular regulation in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. The action of ANG II endogenous to the VLM was examined by microinjection of 100 pmol of [Sar1,Thr8]ANG II into either the rostral (R) or caudal (C) VLM. This ANG II antagonist caused depressor and bradycardic responses in the RVLM and pressor and tachycardic responses in the… CONTINUE READING

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