Ventricular unloading is associated with increased 20s proteasome protein expression in the myocardium.

@article{Wohlschlaeger2010VentricularUI,
  title={Ventricular unloading is associated with increased 20s proteasome protein expression in the myocardium.},
  author={Jeremias Wohlschlaeger and Stephan Urs Sixt and Tatjana Stoeppler and Klaus Juergen Schmitz and Bodo Levkau and Konstantinos Tsagakis and Christian Vahlhaus and Christof Schmid and Juergen Peters and Kurt Werner Schmid and Hendrik Milting and Hideo Baba},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2010},
  volume={29 1},
  pages={125-32}
}
BACKGROUND The ubiquitin-proteasome system (UPS) breaks down misfolded and normal proteins, including cell cycle regulatory proteins involved in cardiac hypertrophy. Because congestive heart failure (CHF) increases cardiomyocyte cellular mass, indicative of increased protein synthesis and/or impaired breakdown, and ventricular unloading decreases cardiac hypertrophy and changes regulation of multiple molecular systems ("reverse cardiac remodeling"), we tested the hypothesis that ventricular… CONTINUE READING