Ventricular hypertrophy and presynaptic regulation of sympathetic function.

  title={Ventricular hypertrophy and presynaptic regulation of sympathetic function.},
  author={Phillip G. Schmid and Carol A. Whiteis and Donald D. Lund},
  journal={The American journal of physiology},
  volume={258 5 Pt 2},
In normal heart, presynaptic cholinergic muscarinic and alpha 2-adrenergic mechanisms contribute to regional variations in the rate constant of norepinephrine turnover (kNE), an index of sympathetic neural function. To evaluate these mechanisms in the hypertrophied heart, pulmonary artery-constricted and sham-operated guinea pigs were pretreated with 1) saline vehicle (control) or 2) a combination of quinuclidinyl benzilate (Q), a muscarinic cholinergic antagonist, and yohimbine (Y), an alpha 2… CONTINUE READING