Ventricular fibrillation-induced intracellular Ca2+ overload causes failed electrical defibrillation and post-shock reinitiation of fibrillation.

@article{Zaugg1998VentricularFI,
  title={Ventricular fibrillation-induced intracellular Ca2+ overload causes failed electrical defibrillation and post-shock reinitiation of fibrillation.},
  author={Christian E. Zaugg and Shao Te Wu and V{\^a}nia dos Santos Barbosa and Peter Buser and Joan Wikman-Coffelt and William Watts Parmley and Randall J. Lee},
  journal={Journal of molecular and cellular cardiology},
  year={1998},
  volume={30 11},
  pages={
          2183-92
        }
}
Despite high efficacy, electrical defibrillation shocks can fail or ventricular fibrillation (VF) is reinitiated after the application of the initial shock. The goal of this study was to determine whether [Ca2+]i overload, induced by VF itself, can cause failed electrical defibrillation and post-shock reinitiation of VF. For this purpose, we simultaneously measured [Ca2+]i transients (assessed by indo-1 fluorescence) and defibrillation energies (assessed by a modified implantable cardioverter… CONTINUE READING
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