Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus.

@article{Sweet2001VentricularCT,
  title={Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus.},
  author={Douglas H. Sweet and David Scott Miller and John B. Pritchard},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={41611-9}
}
To determine whether organic cation transporter (OCT) family members might mediate choline transport in choroid plexus (CP), the handling of choline by cloned transporters and by intact CP isolated from the adult rat was investigated. Expression of OCT1 and OCT2 in Xenopus oocytes increased hemicholinium-3-sensitive choline uptake. In contrast, OCT3 did not mediate choline transport. Estimated K(m) values for choline in rOCT1-, rOCT2-, and hOCT2-expressing oocytes were 346 +/- 50, 441 +/- 67… CONTINUE READING