Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding.

@article{Hodge1993VentralTM,
  title={Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding.},
  author={Clyde W Hodge and Masashi Haraguchi and H L Erickson and Herman H. Samson},
  journal={Alcoholism, clinical and experimental research},
  year={1993},
  volume={17 2},
  pages={370-5}
}
The effects of microinjections in the ventral tegmental area (VTA) of the dopamine D2/D3 agonist quinpirole on ethanol- and sucrose-reinforced responding were tested. Two groups of Long-Evans rats were trained to lever press on a fixed-ratio 4 schedule with 10% ethanol (v/v) (n = 8) and 75% sucrose (w/v) (n = 10) presented as the reinforcer. Weekly bilateral injections of quinpirole were tested in the ethanol group (0.0, 0.001, 0.01, 0.1, and 1.0 micrograms/microliters) and sucrose group (0.0… CONTINUE READING

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