Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.

  title={Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.},
  author={Sarah Dubreucq and Audrey Durand and Isabelle Matias and Giovanni B{\'e}nard and Elodie M. Richard and Edgar Soria-G{\'o}mez and Christelle Glangetas and Laurent Groc and Aya Wadleigh and Federico Massa and Dusan Bartsch and Giovanni Marsicano and François Georges and Francis Chaouloff},
  journal={Biological psychiatry},
  volume={73 9},
BACKGROUND We have shown that the endogenous stimulation of cannabinoid type-1 (CB₁) receptors is a prerequisite for voluntary running in mice, but the precise mechanisms through which the endocannabinoid system exerts a tonic control on running performance remain unknown. METHODS We analyzed the respective impacts of constitutive/conditional CB₁ receptor mutations and of CB₁ receptor blockade on wheel-running performance. We then assessed the consequences of ventral tegmental area (VTA) CB… CONTINUE READING
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