Ventral striatum lesions enhance stimulus and response encoding in dorsal striatum.

@article{Burton2014VentralSL,
  title={Ventral striatum lesions enhance stimulus and response encoding in dorsal striatum.},
  author={Amanda C Burton and Gregory B Bissonette and Nina T. Lichtenberg and Vadim Kashtelyan and Matthew R Roesch},
  journal={Biological psychiatry},
  year={2014},
  volume={75 2},
  pages={132-9}
}
BACKGROUND The development of addiction is thought to reflect a transition from goal-directed to stimulus-response driven behavior, functions attributed to ventral (VS) and dorsal striatum (DS), respectively. In line with this theory, neuroadaptations that occur during prolonged drug use progress from VS to DS. Here we ask if VS dysfunction alone, independent of drug use, can affect neural selectivity in DS. METHODS To address this issue, we recorded from single neurons in DS while rats… CONTINUE READING

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