Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability

@inproceedings{Miller2017VentralSR,
  title={Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability},
  author={M. L. Miller and Y Ren and Henrietta Szutorisz and N A Warren and Chloe Tessereau and Gabor Egervari and Agnieska E. Mlodnicka and Manoj Kapoor and Bader Chaarani and C V Morris and Gunter Schumann and Hugh Garavan and A M Goate and M J Bannon and J Halperin and Y. L. Hurd},
  booktitle={Molecular Psychiatry},
  year={2017}
}
Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood. Here we report the critical role of ventral striatal cAMP-response element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability. Using an ADHD rat model… CONTINUE READING
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