Ventral striatal activation during reward differs between major depression with and without impaired mood reactivity

  title={Ventral striatal activation during reward differs between major depression with and without impaired mood reactivity},
  author={Jens Foell and Julia Klawohn and Alec Bruchnak and Christopher J. Brush and Christopher J. Patrick and Greg Hajcak},
  journal={Psychiatry Research: Neuroimaging},
Manipulating Reward Sensitivity Using Reward Circuit-targeted Transcranial Magnetic Stimulation.
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The objective of this study is to conduct a systematic review and meta-analysis to assess the effect of psychosocial interventions in reducing problematic Internet use (PIU), anxiety, and depression


Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.
Results suggest that basal ganglia dysfunction in major depression may affect the consummatory phase of reward processing, and morphometric results suggest that anhedonia in major Depression is related to caudate volume.
Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties
The caudate is identified as a region with dissociable incentive-dependent dACC connectivity abnormalities in major depressive disorder, and initial evidence that cortico-striatal circuitry may play a role in MDD treatment response is provided.
Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals
Pretreatment measures of reward-related VS activity may serve as objective neural markers to advance efforts to personalize interventions by guiding individual-level choice of antidepressant treatment.
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia
New evidence of reward processing abnormalities in MDD, bipolar disorder and schizophrenia has led to a greater understanding of the neural processes associated with symptomatology common across these conditions, andsecting various subcomponents of rewardprocessing that map onto partially different neurobiological pathways and investigating their dysregulation in different psychiatric disorders holds promise for developing more targeted, and hopefully efficacious treatment and intervention strategies.
Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram
It is suggested that MDD patients show ventral striatal hyporesponsiveness during incentive cue processing, which normalizes after successful treatment, as well as group-by-time interaction during anticipation of loss.
Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology
Findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS, which is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.
Reduced neural response to reward and pleasant pictures independently relate to depression
It is suggested that a blunted RewP and LPP reflect independent neural deficits in MDD – which could be used in conjunction to improve the classification of depression.