Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.

@article{CasteloBranco2006VentralMG,
  title={Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.},
  author={Gonçalo Castelo-Branco and Kyle M. Sousa and V{\'i}tězslav Bryja and Lu{\'i}sa Pinto and Joseph P. Wagner and Ernest Arenas},
  journal={Molecular and cellular neurosciences},
  year={2006},
  volume={31 2},
  pages={251-62}
}
Glial cells have been classically described as supporting cells for neurons. Recently, additional roles during neural development have begun to emerge. Here, we report that ventral midbrain glia, including astrocytes and radial glia, are the source of signals required by neural precursors to acquire a dopaminergic phenotype. We found that ventral midbrain glia, but not cortical glia, secrete high levels of the glycolipoprotein Wnt-5a, express region-specific transcription factors such as Pax-2… CONTINUE READING

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