Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin

Abstract

In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. Selective pharmacogenetic inactivation of these neurons inhibited context-induced drug relapse. A small subset of ventral mPFC neurons formed neuronal ensembles that… (More)
DOI: 10.1038/nn.2758

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@inproceedings{Bossert2011VentralMP, title={Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin}, author={Jennifer M Bossert and Anna L. Stern and Florence R. M. Theberge and Carlo Cifani and Eisuke Koya and Bruce T Hope and Yavin Shaham}, booktitle={Nature Neuroscience}, year={2011} }