Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide.

@article{Vassilakopoulos2007VentilatoryMA,
  title={Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide.},
  author={Theodoros Vassilakopoulos and Sabah N. A. Hussain},
  journal={Journal of applied physiology},
  year={2007},
  volume={102 4},
  pages={1687-95}
}
Strenuous diaphragmatic contractions that are induced by inspiratory resistive breathing initiate an inflammatory response that involves the elevation of pro- and anti-inflammatory cytokines within the diaphragm, which may then spill into the circulation. The production of reactive oxygen species within working respiratory muscles increases in response to these strenuous diaphragmatic contractions. At the same time, diaphragmatic nitric oxide (NO) production declines significantly, despite a… CONTINUE READING